Let's first sort out the classification of nicotinic insecticides.
The first generation of nicotine products: imidacloprid (1991 Bayer), nitenpyram (1995 Takeda), acetamiprid (1996 Japan Caoda), thiacloprid (2000 Bayer). The main intermediate is 2-chloro-5-chloromethylpyridine, which belongs to the chloropyridyl group.
Second-generation nicotine products: thiamethoxam (1998 Novartis), clothianidin (2002 Bayer, Takeda). The main intermediate is 2-chloro-5-chloromethylthiazole, which belongs to the chlorothiazolyl group.
The third generation of nicotine products: dinotefuran (Mitsui, Japan in 2002), the tetrahydrofuran group has replaced the chloro group, and does not contain halogen elements.
The mechanism of nicotine insecticidal action is to act on the nerve transmission system of insects, making them abnormally excited, paralyzing and dying, and also has the effects of contact killing and stomach poisoning. Compared with traditional nicotines, dinotefuran does not contain halogen elements, and its water solubility is stronger, which means that dinotefuran is more easily absorbed; and its oral toxicity to bees is only 1/4.6 of that of thiamethoxam , contact toxicity is half of thiamethoxam.
Dinotefuran Incremental Analysis:
1. Dinotefuran has a wider insecticidal spectrum and application range, from pesticides to hygienic drugs, from small insects to large insects, and has a good control effect.
2. Good mixability, dinotefuran can be mixed with a variety of insecticides and fungicides, which is convenient to use; the formulations are rich, and it can be made into granule fertilizer, seed coating agent for seed dressing, and suspension agent for spraying.
3. Rice can control borers and planthoppers with one drug and two kills. It is cost-effective and will be a huge market opportunity for the future growth of dinotefuran.
4. The popularity of flight control. Dinotefuran is easily soluble in water, which makes it more suitable for large-scale use of flight control. The popularization of flight control will provide a rare market opportunity for the future development of dinotefuran.
5. The dextrorotary enantiomer of dinotefuran mainly provides insecticidal activity, and the levorotatory enantiomer is highly toxic to Italian honeybees. It is believed that with the breakthrough of purification technology, dinotefuran, which is more environmentally friendly, will break through its own development bottleneck.
6. Focus on niche crops. With the enhanced resistance of leek and garlic maggots to common chemicals, dinotefuran has performed well in the control of maggot pests, and the application of dinotefuran in niche crops will also provide a new market for the development of dinotefuran and direction.
7. The improvement of cost performance. The biggest obstacle affecting the growth of dinotefuran has always been the high price of the original drug, and the application cost of the terminal preparation is relatively high. However, the price of dinotefuran is currently at a relatively low level in history. With the decline in price, the price-performance ratio of dinotefuran has become more and more prominent. We believe that the improvement in price-performance ratio provides more possibilities for the future growth of dinotefuran.
