Bixlozone is a broad-spectrum selective herbicide mainly used in sugarcane, rape, rice, cotton, soybean and other crop fields to control annual weeds. This product has been widely used since its launch, and Brazil holds about 1/3 of the market share; non-crops, sugar cane, and rapeseed are its most important application areas.
Chemical structure and physical and chemical properties
Product Name: Bixlozone
Development code: F9600
Trade names: Isoflex™, Overwatch®, Fengqu®, etc.
IUPAC chemical name: 2-(2,4-dichlorobenzyl)-4,4-dimethylisoxazolin-3-one
CAS NO.: 81777-95-9
Molecular formula: C12H13Cl2NO2
Molecular weight: 274.14
Melting point: 81.5℃
Boiling point: Decomposes before boiling
Vapor pressure: 2.3×10-9 Pa (20℃)
Solubility in water: 39.6 mg/L (20℃)
N-octanol-water partition coefficient: KowlgP=3.3 (pH 7, 20℃)
Structural formula:
Mechanism of action and application
Bixlozone is a deoxy-D-xyluose phosphate synthase (DEOXY-D-XYLULOSE PHOSPHATE SYNTHASE; DOXP or DXS for short) inhibitor. Classified as Group F4 (or HRAC/WSSA Group 13) by the International Herbicide Resistance Action Committee (HRAC). Currently, there are only 2 active ingredients in this group, bixlozone and clomazone.
Bixlozone disrupts plastid isoprenoid biosynthesis and blocks carotenoid synthesis by inhibiting deoxy-D-xylulose phosphate synthase (DOXP). As a result, susceptible plants cannot perform photosynthesis normally, and the plants turn white, yellow, or lose green, stop growing, and die.
Deoxy-D-xylulose phosphate synthase is the first rate-limiting enzyme of the mevalonate (MEP) pathway and the key regulatory enzyme of the pathway. It plays a key regulatory role in the synthesis of monoterpene and diterpene aroma compounds, carotenoids, chlorophyll and other important substances.
Bixlozone is mainly absorbed through the roots and seedlings of plants, and is conducted upward from the roots through transpiration. It is transported to various parts of the plant through the xylem (not conducted downward or between leaves), hindering plant photosynthesis and causing sensitive plants to die in a short period of time.
Bixlozone is a broad-spectrum selective herbicide with systemic and contact effects. Mainly used in crop fields such as fruit trees, vegetables, rice, cereals (including barley, wheat, sorghum, rye, etc.), corn, legumes, cotton, sugar beet, rapeseed, sugar cane, etc. Controls broadleaf weeds, grass weeds, sedges, etc., and is effective against difficult-to-control weeds such as ryegrass. It has a long application window period and good persistence. It can be applied at the time of sowing or before or after emergence. It not only has a good control effect on weeds that have already occurred, but also has a certain control effect on weeds that occur later, and the effect lasts up to 12 weeks. It can be used for resistance management and is effective against some resistant weeds. In addition, Bixlozone products are currently the only herbicides that can be used in three major winter crop fields, including wheat, barley, and rapeseed, providing greater flexibility for crop rotations.
